<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:01a0cf5b-79b6-7152-bbdd-da4ef74bf1a7,g:371c1b3b-6819-4bbc-96d3-b64062156d59-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.gossamerbio.com/role/Cover" xlink:type="simple" xlink:href="goss-20260923.xsd#Cover"/>
  <link:presentationLink xlink:role="http://www.gossamerbio.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_01a0cf5b-79b6-7272-a8b9-6172b78d3459" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_DocumentType_01a0cf5b-79b6-7272-a8b9-6172b78d3459" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_01a0cf5b-79b6-7594-8e8e-876b78f0d2ad" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_DocumentPeriodEndDate_01a0cf5b-79b6-7594-8e8e-876b78f0d2ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_01a0cf5b-79b6-7ae9-b781-851cb1a18fd8" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_EntityRegistrantName_01a0cf5b-79b6-7ae9-b781-851cb1a18fd8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_01a0cf5b-79b6-7a00-a693-1c2ab1377c60" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_EntityIncorporationStateCountryCode_01a0cf5b-79b6-7a00-a693-1c2ab1377c60" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_01a0cf5b-79b6-7d9d-b605-0eaed7c82f9e" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_EntityFileNumber_01a0cf5b-79b6-7d9d-b605-0eaed7c82f9e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_01a0cf5b-79b6-7b19-b72f-54f411ccf2de" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_EntityTaxIdentificationNumber_01a0cf5b-79b6-7b19-b72f-54f411ccf2de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_01a0cf5b-79b6-7828-a7c1-668c3de5e91f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_EntityAddressAddressLine1_01a0cf5b-79b6-7828-a7c1-668c3de5e91f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_01a0cf5b-79b6-7122-8f93-9d5332a11ca5" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_EntityAddressCityOrTown_01a0cf5b-79b6-7122-8f93-9d5332a11ca5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_01a0cf5b-79b6-7235-babf-540de8d915d8" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_EntityAddressStateOrProvince_01a0cf5b-79b6-7235-babf-540de8d915d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_01a0cf5b-79b6-7d37-a762-4a4986eb9ce2" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_EntityAddressPostalZipCode_01a0cf5b-79b6-7d37-a762-4a4986eb9ce2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_01a0cf5b-79b6-7c4c-8b05-12ce4bedbc8a" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_CityAreaCode_01a0cf5b-79b6-7c4c-8b05-12ce4bedbc8a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_01a0cf5b-79b6-7e82-bc80-104fe7baa966" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_LocalPhoneNumber_01a0cf5b-79b6-7e82-bc80-104fe7baa966" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_01a0cf5b-79b6-7c0f-b556-0b22bec43b9e" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_WrittenCommunications_01a0cf5b-79b6-7c0f-b556-0b22bec43b9e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_01a0cf5b-79b6-7191-8fe2-d1f49167a8ca" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_SolicitingMaterial_01a0cf5b-79b6-7191-8fe2-d1f49167a8ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_01a0cf5b-79b6-7ede-b616-8e8a9105f5ef" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_PreCommencementTenderOffer_01a0cf5b-79b6-7ede-b616-8e8a9105f5ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_01a0cf5b-79b6-760c-b7ab-1091f24b405b" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_01a0cf5b-79b6-760c-b7ab-1091f24b405b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_01a0cf5b-79b6-7f66-9884-0b11a144818f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_Security12bTitle_01a0cf5b-79b6-7f66-9884-0b11a144818f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_01a0cf5b-79b6-707b-a673-f26f2259c8f7" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_TradingSymbol_01a0cf5b-79b6-707b-a673-f26f2259c8f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_01a0cf5b-79b6-764b-8dfd-2dd0c30c21e4" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_SecurityExchangeName_01a0cf5b-79b6-764b-8dfd-2dd0c30c21e4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_01a0cf5b-79b6-7778-a4a9-3745d6fdc441" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_EntityEmergingGrowthCompany_01a0cf5b-79b6-7778-a4a9-3745d6fdc441" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_01a0cf5b-79b6-777f-9e3f-d49e8acfaace" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_EntityCentralIndexKey_01a0cf5b-79b6-777f-9e3f-d49e8acfaace" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_01a0cf5b-79b6-7e7b-9a84-772342588149" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0cf5b-79b6-7281-ba00-d6ce6f07c52a" xlink:to="loc_dei_AmendmentFlag_01a0cf5b-79b6-7e7b-9a84-772342588149" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
